Insufflation (Intranasal) Method: The Jaguar’s Path

“Jaguars don’t smoke,” wrote psychedelic pioneer Ralph Metzner in The Toad and the Jaguar, reflecting on the wild immediacy of the smoked 5-MeO-DMT experience. In contrast, when the medicine is taken intranasally—via insufflation—it invites a slower, more spacious journey. This method allows the experience to unfold gradually, with a longer duration and a gentler ascent. For many, this slower onset provides a more accessible terrain for inner work, enabling participants to stay connected to the body, breath, and heart while navigating expanded states of consciousness.

The internasal method is not new. For centuries, Indigenous peoples of the Orinoco Basin in the Amazon and the Caribbean used a powerful snuff known as Yopo, made from the seeds of the cohoba tree, to access the visionary and healing properties of 5-MeO-DMT-containing plants. The modern intranasal approach is a respectful homage to those early traditions. It use lab-tested, synthetic 5-MeO-DMT, what Metzner called the “Jaguar” medicine, which is then combined with a gentle herbal snuff that supports absorption and eases the physical process. This route is ideal for those with sensitive lungs or who seek a more grounded, trauma-informed experience. It also honors the ancestral wisdom that recognized the potential of this molecule long before it was known to the modern world, whether in sacred plants or in the secretion of the Sonoran Desert Toad (Incilius alvarius).

Why Intranasal Matters
For those with sensitive lungs, or who feel apprehensive about the intensity of vaporized toad or synthetic medicine, the intranasal route offers a deeply grounding alternative. We administer a precise blend of 5-MeO-DMT with a carefully chosen herbal snuff, which not only facilitates absorption but enhances the somatic quality of the experience. This method is particularly well-suited for trauma-informed care, titrated psychedelic work, and group sessions where attunement and integration are essential. Rather than being propelled into dissolution, participants are invited to settle into it—offering more room for the psyche to unfold, the body to guide, and the heart to open.